PROTECTING THE OLDER BRAIN!

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April 2, 2025

Weight Training Protects Brain Health in Older Adults with Mild Cognitive Impairment

A new study from the State University of Campinas (UNICAMP) in Brazil reveals that weight training not only enhances physical strength but also protects the brains of older adults with mild cognitive impairment (MCI). After six months of twice-weekly resistance training, participants showed significant memory improvements and protection against brain atrophy in regions linked to Alzheimer’s disease.

Key Findings

  • Brain Protection: Weight training preserved the volume of the hippocampus and precuneus, areas crucial for memory and cognition.

  • Improved Memory: Participants demonstrated better verbal episodic memory after six months of training.

  • Low-Cost Prevention: Strength training offers an affordable, effective alternative to expensive dementia medications.

Study Overview

The research, published in GeroScience, involved 44 older adults diagnosed with MCI—an intermediate stage between normal aging and Alzheimer’s disease. Participants were divided into two groups:

  • Training Group: Engaged in moderate- to high-intensity weight training twice a week.

  • Control Group: Did not participate in any structured exercise program.

At the end of the study, MRI scans revealed that those in the training group maintained better white matter integrity, while the control group showed a decline. The findings suggest that weight training may slow or even reverse early cognitive decline.

The Science Behind the Benefits

Weight training appears to protect brain health through two mechanisms:

  1. Neural Growth Factors: Exercise stimulates the production of brain-derived neurotrophic factor (BDNF), essential for neuron growth and survival.

  2. Anti-Inflammatory Effects: Resistance training reduces inflammation, which is linked to cognitive decline and neurodegenerative diseases.

“Our study shows that weight training is a powerful ally against dementia, even for individuals already at high risk,” says Isadora Ribeiro, lead researcher and FAPESP doctoral fellowship recipient.

Public Health Implications

The researchers emphasize the need for more physical education programs in public health systems. “New anti-amyloid drugs for dementia cost around $30,000 per year. In contrast, weight training is a cost-effective, non-pharmacological intervention that benefits both brain and body,” explains Marcio Balthazar, study supervisor and BRAINN researcher.

Future Research

The study suggests that longer training periods could yield even greater cognitive improvements. Some participants even saw their MCI diagnosis reversed by the end of the trial. Future research will explore the long-term effects of resistance training and its relationship with key biomarkers like BDNF and irisin.

Source: Neuroscience News
Original Research: Ribeiro et al., GeroScience

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